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IL-1 BETA AND IL-6 CYTOKINES PROFILE IN OBESE AND OVER WEIGHT WOMEN IN

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 اسراء عدنان ابراهيم البغدادي
22/10/2017 07:14:29
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The occurrence of obesity has augmented fast through new year. Our previous study showed obesity was related
with diseases and or infections recorded, adipose tissue mediates immune system. Present study aim is evaluation
some immune aspect related with IL-1- Beta as pro-inflammatory cytokine and IL-6 cytokine as both pro and anti-
inflammatory cytokine) production in obese versus normal weight women. Enzyme-linked immune sorbent assay
(ELISA) used for detecting and quantifying cytokines. Results shows that the concentration of the IL-1Beta as pro
inflammatory cytokine stood greater in obese and overweight women (186.2 ± 58.54, n=17) than in normal weight
women (control group (20.41 ± 9.387, n=3), (F=220.4, P < 0.05) while here stayed not any substantial variances in
IL-6 concentrations between test group (198.5 ± 34.93, n=15) in compare with control group (212.6 ± 122.9, n=3),
(F=2.475, P=0.240). In conclusion, our result improved that obesity responsible in elevation level of pro-
inflammatory cytokine IL-1 Beta and interleukin 6 play important role as both anti and proinflammatory cytokine.
The occurrence of obesity has augmented fast through new year. Our previous study showed obesity was related
with diseases and or infections recorded, adipose tissue mediates immune system. Present study aim is evaluation
some immune aspect related with IL-1- Beta as pro-inflammatory cytokine and IL-6 cytokine as both pro and anti-
inflammatory cytokine) production in obese versus normal weight women. Enzyme-linked immune sorbent assay
(ELISA) used for detecting and quantifying cytokines. Results shows that the concentration of the IL-1Beta as pro
inflammatory cytokine stood greater in obese and overweight women (186.2 ± 58.54, n=17) than in normal weight
women (control group (20.41 ± 9.387, n=3), (F=220.4, P < 0.05) while here stayed not any substantial variances in
IL-6 concentrations between test group (198.5 ± 34.93, n=15) in compare with control group (212.6 ± 122.9, n=3),
(F=2.475, P=0.240). In conclusion, our result improved that obesity responsible in elevation level of pro-
inflammatory cytokine IL-1 Beta and interleukin 6 play important role as both anti and proinflammatory cytokine.

  • وصف الــ Tags لهذا الموضوع
  • Obesity, IL-1Beta, IL-6, pro inflammatory cytokines