Thyroid function is affected by AAS used in humans, although the mechanisms of
the effects of androgenic anabolic steroid (AAS) are unclear. The present study is
designed to know the effect of AAS in thyroid function and oxidative stress.
Experimental animals used in the study(30 Swiss mice) were allocated to three
groups as general control group, and test groups(N=10). The test groups received
(5,10) mg/kg of body weight nandrolone Decanoate by subcutaneous injection each 48
hours , but control groups received the same volume of normal saline . The duration
of the experiment was 4-weeks. Blood samples were collected after two days at the
end of experimental period from the control and treated groups. The serum samples
were assayed for (TSH,T3,T4, total cholesterol , MDH,GSH,) Results revealed that all
ND-treated animals exhibited a significant increase of body weight (B.W) and serum
TSH hormone, total cholesterol, MDA, a significant decrease was found in GSH
level,T3 and T4 hormone, Our data of this study indicate that anabolic steroids at
supraphysiological doses exerts direct actions on the thyroid gland and might lead to
thyroid dysfunction and increase of oxidative stress of males .Testosterone or its
derivatives such as Nandrolone Decanoate are being problem commonly. Athletes,
coaches, and physicians should be aware of their harmful side effects.