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The Possible Protective Effect of Green Tea Extract against Methotrexate - Induced Liver Injury in Male Rats

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 داليا عبدالزهرة محسن الصراي
24/02/2019 08:45:31
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This study was performed to evaluate the influence of simultaneous administration of aqueous
green tea extract (1.5 %) with methotrexate (0.5 mg /kg) on the status of glutathione (GSH) in liver
tissue, with measuring the activity of serum liver enzymes [alanine aminotransferase (ALT), aspartate
aminotransferase (AST)] and serum bilirubin levels. Administrations of aqueous green tea extract alone
resulted in a significant increase in liver tissue GSH level and when it was used with MTX it
ameliorated MTX-induced changes in level of this parameter. Regarding enzymes activities,
administration of aqueous green tea extract resulted in an alleviating effect on MTX-induced elevation
in serum ALT activity with a non-significant reduction in serum AST activity; it also significantly
reduced MTX-induced elevation in total serum bilirubin level, these effects may be related to direct or
indirect antioxidant property of green tea extract .

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  • Protective Effect of Green Tea Extract against Methotrexate Induced Liver Injury