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The role of tumor necrosis factor-alpha (TNF-alpha) in the induction of preterm labor

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 محمد عبد كاظم حسن المزيداوي
5/2/2011 6:33:04 PM
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The role of tumor necrosis factor-alpha (TNF-alpha)
in the induction of preterm labor
 Karbala J Med.3(1)2010:779-783
 
 Mohammad Sabri A. Razzak* Mohammad A. K. Al-Sa’adi* Taiseer Abdul Ilah AL Hussainy* * *College of Medicine/ Babylon University ,**College of medicine-Al-Muthana university
 
Abstract:
 
 Background: Microbial colonization and inflammation in the maternal genital tract has emerged as one of the major risk factors associated with spontaneous preterm birth.
 
Objectives: this study aimed to demonstrate the role of tumor necrosis alpha(TNF-alpha)in the induction of preterm labor.
 
Materials and methods: This study was conducted in Babylon Teaching Hospital of Gynecology and Pediatrics from November 2007 to May 2008. A total of 60 pregnant women with preterm labor admitted to Labor Room and 20 control women (10 of them were pregnant at term with bacterial infection, 5 were pregnant at term without bacterial infection, and 5 were normal females not pregnants and not infected) were included in this study. The ages of patients and controls ranged from (17-40) years. Blood samples were collected from both patients and controls to estimate tumor necrosis factor alpha (TNF-alpha by EASIA (Enzyme Amplified Sensitivity Immunoassay) method.
 
 Results: The results show there is significantly higher (p<0.05) in the level of TNF- alpha in patients with preterm labor compared to all control groups. Conclusion: The results clearly indicate the possible role of TNF-? in the induction of preterm labor. Keywords: preterm labor, TNF-alpha


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