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6/11/2011 6:18:00 PM
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Typhoid Fever Complications in Babylon
Published In MJB 2008 ( 4) ; 2
Prof. Dr. Monem Alshok , Dr Baha’a Alamidi ,
MB Ch B, M D , C A B M . PhD,Bacteriology,
College of Medicine , Babylon University . College of Dentistry
Abstract :
635 patients with acute febrile illnesses admitted to Merjan teaching hospital during the period from Jan. 1996 to March 1997. Blood culture had been performed on all these patients and Salmonella typhi were isolated in 65 patients ( Isolation rate of 10.25 % ) .
The age incidence of these 65 cases ,range from ( 11 – 35 ) years , with a mean of 18.8 years . 29 are males and 36 are females .
The complications during the course of the disease were studied in these 65 patients,and bowel haemorrhage & perforation are still present. We had noticed oral soreness and oral ulceration in two female patients with Typhoid fever .
Key words : Typhoid Fever , Complications , a clinical study in Babylon .
Address : E mail : monem _ alshok @ yahoo. com
Introduction :
Typhoid fever is one type of generalized infection caused by salmonella typhi and para typhi ( A , B , & C ) . The natural history of typhoid fever established first in 1856 by William Budd , in 1880 Eberth described the typhoid bacillus. The term Enteric fever was first introduced in 1869 . (1) , (2) .
Typhoid fever remains a prevalent disease in developing countries as a result of adverse socio-economic factors . Variant presentations of typhoid fever had been demonstrated which include, mild , abortive type ; meningotyphoid ;nephrotyphoid ;peumo- and pleuro – types ; hemorrhagic typhoid & hepatic typhoid .(3)
In typhoid bacteraemia , we have a large decrease in neutrophils count, which is mostly due to altered adhesiveness of neutrophils to endothelial lining of blood vessels .(4) Furthermore Salmonella is a facultative intracellular parasite and can invade macrophage & survive and resist inactivation ; and inaddition the major finding incomplicated cases of typhoid fever was the negative leucocytes migration inhibition test .(5)
For diagnosis of typhoid fever all serologic tests are non-specific, poorly standariesed , often confusing and difficult to interpret .(6),(7), (8) .We depend on blood culture and / or bone marrow culture for diagnosis of typhoid fever and we sudy the complications in this condition .
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