Reproductive impairment in poorly controlled type one diabetes mellitus results from perturbations
at different levels of the gonadotropic axis, including the hypothalamus/pituitary and the
ovary.
Aims of the study To assess the levels of anti-Mullerian hormone in women with type I diabetes mellitus during
their reproductive age period.
This study was designed as a case-control study. We evaluated anti-Mullerian hormone serum
level in a female with type I diabetes mellitus (N = 60) who attended the Diabetes and Endocrine Center
in Merjan Medical city in Babylon, from November 2015 to April 2016. These patients were compared
with a healthy fertile female (N = 80) as a control group. The female’s age ranges from 13 to 40 years
for the two groups. Body mass index was calculated and serum samples for anti-Mullerian hormone
serum levels were estimated. There was a significant difference between patients and control group regarding body mass
index, residence, educational level, fertility, and menarche. Anti-Mullerian hormone level is significantly
lower in patient group when compared with the control group (p = 0.000?). HbA1c level is significantly
higher in a patient group when compared with the control group (p = 0.000?).
The results suggest that type I diabetes is an independent risk factor for decrease of anti-
Mullerian hormone level in reproductive age group women.