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Thalassemia refers to spectrum of hereditary anemias
characterized by reduced or absent production of one
or more globin chain.1
Regular blood transfusions
from an early age are essential therapy for child with
beta-thalassemia major in order to achieve optimal
growth and adequate organ function as well as improve
survival.2
Every unit of packed blood cell contain 200-
250 mg of iron. This rate of transfusion leads to iron
deposition in the body, of about 15-20 mg/day, with
aiming of good chelation therapy to remove more than
15-20 mg/day to achieve negative iron balance.3
Iron
overloaded is a main cause of morbidity and mortality
in transfusion-dependent thalassemic patients.4

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