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# 1 Inorganic Pharmaceutical Chemistry

الكلية كلية العلوم للبنات     القسم قسم الكيمياء     المرحلة 3
أستاذ المادة محمد حامد سعيد الدهيمي       19/12/2012 18:23:58
Inorganic Pharmaceutical Chemistry
3rd Class 1st Semester 2012/2013
Reference text:-
1- Inorganic Medicinal and Pharmaceutical Chemistry
by Block ,Roche Soine and Wilson
2- Textbook of Organic Medicinal and Fharmaceutical Chemistry by Wilson and Gisvold
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Lecture No. 1 Date : 4/10 2012
Dr. Mohammed Hamed
Atomic & Molecular Structural Complexation
atom is composed of a nucleus (about 10-15m in diameter) at the centre which contains most of the mass of the atom, and orbiting electrons (negatively charged particles), which have negligible mass.
The nucleus is composed of protons (positively charged fundamental particles), and neutrons (uncharged fundamental particles).
The radius of an atom is roughly 10,000 times larger than the diameter of the nucleus, i.e. it is about 10-10m, or 1 angstrom ).
relative mass relative charge
proton 1 +1
neutron 1 0
electron 1/1836 -1
These figures illustrate the fact that practically all of the mass of the atom is contained within a very small region
Atoms can be described by two numbers: the atomic number (Z), which is equal to the number of protons the atom contains, and the mass number (A), which is equal to the number of protons plus neutrons.

Working out the numbers of protons and neutrons
No of protons = ATOMIC NUMBER of the atom
The atomic number is also given the more descriptive name of proton number.
No of protons + no of neutrons = MASS NUMBER of the atom
The mass number is also called the nucleon number.
This information can be given simply in the form: 199F
How many protons and neutrons has this atom got?
The atomic number counts the number of protons (9); the mass number counts protons + neutrons (19). If there are 9 protons, there must be 10 neutrons for the total to add up to 19.
The atomic number is tied to the position of the element in the Periodic Table and therefore the number of protons defines what sort of element you are talking about. So if an atom has 8 protons (atomic number = 8), it must be oxygen. If an atom has 12 protons (atomic number = 12), it must be magnesium.
Isotopes:- The number of neutrons in an atom can vary within small limits. For example, there are three kinds of carbon atom 12C, 13C and 14C. They all have the same number of protons, but the number of neutrons varies.

protons neutrons mass number
carbon-12 6 6 12
carbon-13 6 7 13
carbon-14 6 8 14
These different atoms of carbon are called isotopes. The fact that they have varying numbers of neutrons makes no difference whatsoever to the chemical reactions of the carbon.
Isotopes are atoms which have the same atomic number but different mass numbers. They have the same number of protons but different numbers of neutrons