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Synthesis of some New [1,3]- Oxazepine -4,7-dione derivatives

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 علاء جعفر محراث الشياش
10/09/2012 09:06:33
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Synthesis and spectroscopic studies of some imines derived from Benzidine and their
conversion to 1, 3-oxazepine derivatives (I)

 

aAlaa J.Mahrath* ,a Saadon A. Aowda b Sabah N Kamil
aChemistry department - College of Science - Babylon University - IRAQ
b Department of Pharmacology –College of Pharmacy-Babylon University .IRAQ

 


Abstract:
In this paper a series of 1,3-oxazepine derivatives have been synthesized through out two pathways.first one synthesis of imines derivatives (w1-w4) by the condensation reaction of different substituted aldehyde such as (p-N,N-dimethylamino , p- N ,N –diethyl amino , p-chloro, and p-bromo)benzaldehyde with unsubstantiated  Benzidine .while the second pathway involve reactions of the prepared imines (w1-w4) via maleic and phthalic anhydride under inert N2 gas and refluxing conditions to produce 1,3- oxazepine -4,7-dione derivatives (w1m-w4m and w1ph –w4ph) respectively . All the compounds were monitored and elucidated by TLC and available spectroscopic tools such as IR and Elemental analysis .

 

Key words: imines, benzylidene and 1, 3-oxazepine-4,7-dione :
*Corresponding author: Alaa Jafear Mahrath.


  • وصف الــ Tags لهذا الموضوع
  • Benzidine ,1,3-Oxazepine