Microbiology, Infections, and Antibiotic Therapy

Vancomycin
? Tricyclic glycopeptide
? Inhibits synthesis of phospholipids and
cross-linking of peptidoglycans
? Activity against gram-positive organisms
? Useful for beta lactam resistant infections
? Widely distributed, penetrates CSF
? Renal elimination, follows creatinine cl.
? Side effects: phlebitis, red man syndrome,
ototoxicity, nephrotoxicityVancomycin
? Tricyclic glycopeptide
? Inhibits synthesis of phospholipids and
cross-linking of peptidoglycans
? Activity against gram-positive organisms
? Useful for beta lactam resistant infections
? Widely distributed, penetrates CSF
? Renal elimination, follows creatinine cl.
? Side effects: phlebitis, red man syndrome,
ototoxicity, nephrotoxicityVancomycin
? Tricyclic glycopeptide
? Inhibits synthesis of phospholipids and
cross-linking of peptidoglycans
? Activity against gram-positive organisms
? Useful for beta lactam resistant infections
? Widely distributed, penetrates CSF
? Renal elimination, follows creatinine cl.
? Side effects: phlebitis, red man syndrome,
ototoxicity, nephrotoxicityVancomycin
? Tricyclic glycopeptide
? Inhibits synthesis of phospholipids and
cross-linking of peptidoglycans
? Activity against gram-positive organisms
? Useful for beta lactam resistant infections
? Widely distributed, penetrates CSF
? Renal elimination, follows creatinine cl.
? Side effects: phlebitis, red man syndrome,
ototoxicity, nephrotoxicityVancomycin
? Tricyclic glycopeptide
? Inhibits synthesis of phospholipids and
cross-linking of peptidoglycans
? Activity against gram-positive organisms
? Useful for beta lactam resistant infections
? Widely distributed, penetrates CSF
? Renal elimination, follows creatinine cl.
? Side effects: phlebitis, red man syndrome,
ototoxicity, nephrotoxicity