Autoimmune disese

Autoimmune disease
Dr. Baha,Hamdi.AL-Amiedi
Ph.D.Microbiology

Paul Ehrish
The term cited by the German immunologist paul Ehrich ( 1854-1915)
To describe the bodys innate aversion
to immunological self - destraction
Autoimmunity :
Normally the immune system known its own tissues as self and does not react to them . Rarely, however there is a breakdown in this recognition and the immune system destroy its own tissue a phenomena termed autoimmunity As specificity repertoires that are expressed by both T- and B-Cells are random it is no surprising that antiself specificites occur , there are mechanism which kill these self - reactive cell , as described earlier , but some escape this surveillance , some autoimmune disease are triggered by microbial antigen which mimic or cross – react with self components Autoimmune diseases is a group of disorders in which tissue injury is caused by humoral (by auto-antibodies) or cell mediated immune response (by auto-reactive T cells) to self antigens.
-An autoimmune disorder may result in:
1-The destruction of one or more types of body tissue
2-Abnormal growth of an organ
3-Changes in organ function