The lmmune system

The immune system component
Dr. Baha, Hamdi. AL-Amiedi
Ph.D.Microbilogy
Immune system :The Immune system comprise a network cells with each other cooperates directly to reach the effectors mechanism. and defense the body .against invaders , back to the (1960) the immune system has been structurally and functionally confined to lymphoid system .Recently however immune system may be of six component as in the :following
immune system may be of six component as in the following
. 1-genetic component
. 2-Haemopietic component
. 3-Reticulo endothelial component
4-complement component
. 5-Lymphoid component
. 6-mucosal component
genetic component: The immune system structures &functions are encoded by set of genes like control Immune response, immunoglobulin synthesis and The genes of MHC system involved in rejection of foreign tissue from a region known as the Major histocompatability complex (MHC) that contain several Polymorphic genes which expressed on the surface of all nucleated cells consist of two classes (class I and class II) .These act as peptide receptors and are important in Antigen presentation after processing the Antigen
Role of genetic component in the immune response
After processing the Antigen these epitopes peptides of bind to MHC molecules and present on the cell surface of antigen presenting cells like macrophage, dendric cells
Class I + epitopes peptide(APC)= recognized by CD-8 T-Cell
((intracellular infection))
Class II +epitopes peptide(APC) =recognized by CD-4 T- Cell
(Extracellular infection )
Reticuloendothelial system
it is a System of cells and tissues whose function include principally phagocytosis and degradation and antigen presentation on the surface of the cells which including fixed macrophage and Circulation in blood. It is filter particular matter from blood. The cells of Reticuloendothelial system organized into dense sheet and fibers form sructura matrix of spleen . bone marrow and lymph nodes
The cells are mononuclear leukocytes in blood in liver is kuppfar cells in spleen is denderitic cells in lung is alveolar cells… ect