immune response

Lectuer (10) PRIMARY &SECONDARY IMMUNE RESPONSE
Dr. Baha, H. AL-Amiedi

Primary Immune Response:
This is the first interaction between the antigen and B-cells ,the B-cells will differentiate and become memory cells for future exposure or become mature plasma cells and produce antibodies .the antibody classes strat with IgM, and described as Antigen specific response . lmmunogen injected intramuscular has greater immune response than an immunogen taken orally . A 25-Year old will have a greater immune response than if it given to child.
Secondary Immune Response:
This is anamestic response . It is also known for response of booster shot , it cause a rapid proliferation and differentiation of B-cells to produce large amount of antibody ( mainly IgG). This response is seen with B-cell and DTH T-Cell. An anemnestic response is faster, more specific and longer lasting than primary immune response.
The antigen type is in these responses is B-dependent-Antigen .The time carve is follow factor influencing Antibody production:
1. Age
2. Nutritional status
3. Route of administration
4. Size and Number of doses
5. Multiple antigens
6. Adjuvant
7. Immunosuppressive agent