Autoimmune disease

Autoimmune disease
Dr.Baha. Hamdi. AL-Amiedie
Ph.D.Microbiology
Paul EhThe term coined by the German immunologist paul Ehrich ( 1854-1915)
To describe the bodys innate aversion
to immunological self - destractionrich
Autoimmunity :
Normally the immune system known its own tissues as self and does not react to them . Rarely, however there is a breakdown in this recognition and the immune system destroy its own tissue a phenomena termed autoimmunity As specificity repertoires that are expressed by both T- and B-Cells are random .
it is no surprising that antiself specificites occur , there are mechanism which kill these self - reactive cell , as described earlier , but some escape this surveillance , some autoimmune disease are triggered by microbial antigen which mimic or cross – react with self components
Autoimmune diseases is a group of disorders in which tissue injury is caused by humoral (by auto-antibodies) or cell mediated immune response (by auto-reactive T cells) to self antigens.
-An autoimmune disorder may result in:
-1-The destruction of one or more
Abnormal growth of an organ2-
Changes in organ function3-
Classification of autoimmune disease:
The organ specific when the specific pathology is confined to particular organ :
(eg:Hashimotos disease , pernicious anaemia , Addisons disease )
And when the pathology is not confined to particular organ the disorder were placed under the head non-organ specific .
systemic lupus erythrematosis, reheumatoid arithritis, dermatomyositis
Moreover autoimmune disorder may overlap that mean a patient have more than one organ-specific disease & more than one systemic disease
Based on the clinical experimental studies it has been suggested that autoimmunity may arise due to an
immunologic imbalance with excessive B-cell activity &diminished suppressor T-cell activity. This imbalance may occur as a consequence of genetic , viral and environmental mechanisms acting singly or combination Organ specific autoimmune diseases

A particular organ is affected due to auto Abs.
For example:
1-Thyroiditis
-Myasthenia gravis
-Type I Diabetes Mellitus
-Perinocous anaemia
-Hashimotos disease
-Graves’ Disease
Multiple Sclerosis
Degeneration of nerves CNS (brain and spinal cord).
Myelin disappear due inflammation

. non-specific autoimmune
complexes accumulate in many tissues and cause inflammation and
Affects many organs or the whole body
1-Systemic lupus erythematosus
2-polymyositis
3-primary sjogrens syndrome
4-
heumatoid Arthritis

Disease of the joints.
Caused by the auto Antibody of IgM type, called as rheumatoid factors.
The synovial fluid of these patients contain increased no. of T-cells & macrophages.
Marked by inflammatory changes in the synovial membrane.
In later stage, deformity develops
Systemic Lupus Erythematosus (SLE)
Skin disease due to the production of antinuclear factor (ANF) symptoms include butterfly –rach on face, fatigue, headaches .
In these patients, LE cell (a mature neutrophil) appears in blood & bone marrow
Function – Phagocytosis in the presence of ANF
strikes women nines more often than men Complex of anti-self antibodies & Antigen deposit in and cause damage to Renal tissue (glomeulonephritis) Triggered by environmental effects in persons who are genetically susceptible.
Diagnosis autoimmune disease:
General signs of autoimmune disease that may have diagnostic value include :
1-Elvated serum gamma globuline
2-presence of autoantibodies
3-Depress levels of serum complement
4-lmmune complex in serum
5-lesion detected on biopsy (e.glomerular lesions) resulting from deposition of immune complexs.
-The goals of treatment are to:
1-Reduce symptoms
2-Control the autoimmune process
3-aintain the body s ability to fight disease
if the autoimmune disorder affects the blood-may need blood transfusions.
Medicines are often prescribed to control or reduce the immune Msystem s response- called immunosuppressive medicines.
in the future gene therapy
vaccines to turn off the autoimmune response