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الكلية كلية الصيدلة
القسم فرع الصيدلانيات
المرحلة 2
أستاذ المادة ظافر قحطان سعيد الامين الماشطة
5/28/2011 1:09:55 PM
Complexation and protein binding
Complexes result from a donor-acceptor mechanism or Lewis acid-base reaction between two or more different chemical constituents. Any nonmetallic atom or ion that can donate an electron pair can serve as the donor while the acceptor (accept a share in the pair of electrons) is frequently a metallic ion. Complexes can be divided broadly into two classes depending on weather the acceptor component is a metal ion or an organic molecule. A third class involving the entrapment of one compound in the molecular frame of another is added later. march
Classification of complexes
I. Metal ion complexes
A. Inorganic type
B. Chelates
C. Olefin type
D. Aromatic type
1. Pi (?) complexes
2. Sigma (?) complexes
3. “Sandwich” compounds
II. Organic molecular complexes
A. Quinhydrone type
B. Picric acid type
C. Caffeine and other drug complexes
D. Polymer type
III. Inclusion/occlusion compounds
A. Channel lattice type
B. Layer type
C. Clathrates
D. Monomolecular type
E. Macromolecular type
This classification does not pretend to describe the mechanism or the type of chemical bonds involved in complexation.
Inorganic complexes
The ammonia molecules in hexamminecobalt (III) chloride [Co(NH3)6]+3Cl–3 are known as the ligand and are said to be coordinated to the cobalt ion. The coordination number of the cobalt ion, or number of ammonia groups coordinated to the metal ion is six. Other complexes ions belonging to the inorganic group include [Ag(NH3)2]+
, [Fe(CN)6]–4, and [Cr(H2O)]+3. Each ligand donates a pair of electrons to form a coordinate covalent link between itself and the central ion having an incomplete electron shell. For example:
Hybridization plays an important part in coordination compounds in which sufficient bonding orbitals are not ordinarily available in the metal ion.
المادة المعروضة اعلاه هي مدخل الى المحاضرة المرفوعة بواسطة استاذ(ة) المادة . وقد تبدو لك غير متكاملة . حيث يضع استاذ المادة في بعض الاحيان فقط الجزء الاول من المحاضرة من اجل الاطلاع على ما ستقوم بتحميله لاحقا . في نظام التعليم الالكتروني نوفر هذه الخدمة لكي نبقيك على اطلاع حول محتوى الملف الذي ستقوم بتحميله .
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