Pathology Inflammation and Neoplasia

INFLAMMATON
Dr. Rafal Al-Saigh MBChB, PhD, FIBMS Pathology Specialist Doctor (Clinical Microbiologist)
Inflammation
reaction of tissues to various injurious stimuli a protective response ? remove the initial cause of cell injury, necrotic cells and tissues have harmful effects like anaphylactic shock, rheumatoid arthritis and atherosclerosis Acute inflammation short duration (few minutes - few days) 1.Vascular changes leading to increased blood flow (hyper?mia). 2.Microvascular structural changes leading to leakage of plasma proteins (exudation). .3Emigration of leukocytes ( neutrophilic) towards the site of injury.

? heat (calor) ? redness (rubor) ? swelling (tumour) ? pain (dolor) ? loss of function (functio l?sa)

Outcomes of Acute Inflammation 1. Complete resolution to histologic and functional normality. 2. Fibrosis: Occurs in .A When inflammation in tissues that do not regenerate. .B After substantial tissue destruction. .C Extensive fibrinous exudates. 3. Abscess formation in pyogenic infection. 4. Progression to chronic inflammation
1. Dilution of toxins. 2. Exudation of protective antibodies. 3. Fibrin formation which delays bacterial spread. 4. Exudation of plasma mediators (complement, coagulation, fibrinolytic and kinin). 5. Exudation of nutrient materials. 6. Promotion of immunity. Benificial