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Liver Function Test (المحاضرات 8-11)

الكلية كلية الصيدلة     القسم فرع الكيمياء     المرحلة 5
أستاذ المادة عبد الحسين مهدي كاظم الجبوري       02/02/2020 20:09:52
Liver Function Test
prof. Dr Abdulhussien M. Aljebory University of Babylon College of Pharmacy 5th class, 1st semesters
Objectives
To understand:
the biochemical functions of the liver;
? the different reasons for jaundice and how the pattern of liver function tests can aid the differential diagnosis of liver disease;
? the more specialist biochemical tests that are available in the investigation of liver disease;
? that minor abnormalities in liver enzyme tests are common in relation to the problem of obesity.
What is the Structure of the liver??
Only about 80% of the cells in the liver are hepatocytes, the remainder consists of endothelial (Kupffer) cells lining the hepatic sinusoids and vascular and supporting tissue cells.
Hepatocytes in the periportal area,
zone 1, receive relatively well-oxygenated blood,
whereas the hepatocytes surrounding the central vein, zone 3, receive blood that has lost much of its oxygen and exchanged other substances with the cells of zones 1 and 2.
Cells in zone 3 are the most susceptible to anoxia and injury by a wide range of toxic substances.
In which liver zone the most enzymes are found?
Cells in zone 1 have relatively high concentrations of the enzymes usually measured in blood for diagnostic purposes (e.g. ALP and the aminotransferases
ALT and AST),
while cells in zone 3 are relatively deficient in these enzymes.
This may help to explain why some patients with centrilobular liver damage may have normal serum enzyme activities.


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