NM blocking agent

A) Non depolarizing agent ( comp.)
D+ nicotinic R= ? Ach + R=
no depolarization= no contraction
*In high dose block ion ch = increase weakness
*They useful to decrease the dose of anesthetics
*Overcome by cholinesterase inhibitor
Fasculation :Small M (face , eye , finger limbs , neck, trunk m)
Benzylisoquinolinium compound
Mivacurium
Cisatracurium
Tubocurarine
Metocurine
Doxaqurine
Aminosteroid compound
Rocuronium
Vecuronium
pancuronium
i/v i/m
*Tubocurarine
*release histamine hypotension
*Atracurium
-pass BBB
-degraded spontaneously in plasma
-release histamine hypotension
-its metabolite cause seizer


*Mivacurium
-metabolized by plasma cholinesterase
-used in short surgical procedure
Rocuronium
-Metabolized in liver
-Exc in bile
-In tracheal intubation in patient with full stomach

*Mivacurium
-metabolized by plasma cholinesterase
-used in short surgical procedure
Rocuronium
-Metabolized in liver
-Exc in bile
-In tracheal intubation in patient with full stomach

*Mivacurium
-metabolized by plasma cholinesterase
-used in short surgical procedure
Rocuronium
-Metabolized in liver
-Exc in bile
-In tracheal intubation in patient with full stomach