pharmacology

Lecture # 3
DRUG CLEARANCE THROUGH METABOLISM
Kinetics of metabolism
1. First-order kinetics
2. Zero-order kinetics

Reactions of drug metabolism
Phase I .
Phase I reactions utilizing the P450 system
Nomenclature .
Specificity
Genetic variability
Inducers:
Inhibitors:

Phase I reactions not involving the P450 system
2. Phase II


DRUG CLEARANCE BY THE KIDNEY
Renal elimination of a drug
1. Glomerular filtration
2. Proximal tubular secretion
3. Distal tubular reabsorption
4. Role of drug metabolism


CLEARANCE BY OTHER ROUTES

Clinical situations resulting in changes in drug half-life

When a patient has an abnormality that alters the half-life of a drug,
adjustment in dosage is required. Patients who may have an increase
in drug half-life include those with
1) diminished renal or hepatic blood
flow, for example, in cardiogenic shock, heart failure, or hemorrhage;
2) decreased ability to extract drug from plasma, for example, in renal
disease; and
3) decreased metabolism, for example, when a concomitant
drug inhibits metabolism or in hepatic insufficiency, as with
cirrhosis. These patients may require a decrease in dosage or less
frequent dosing intervals.
In contrast, the half-life of a drug may be
decreased by increased hepatic blood flow, decreased protein binding,
or increased metabolism. This may necessitate higher doses or
more frequent dosing intervals.