Hypersensitivity type II

Type II hypersensitivity
*Learning objectives:
1-Define Ab-mediated disorders.
2-Identify types of Ags in type II hypersensitivity.
3-List the effector mechanisms of type II hypers.
4-Discuss the mechanism of opsonisation and phagocytosis.
5-Explain the mechanism of complement & FC Receptor-mediated inflammation.
6-Explain mechanism of Ab-mediated cellular dysfunction.
Type II hypersensitivity
-Definition.
Type II hypersensitivity
-Types of antigenes:
1-
2-
3-
Type II hypersensitivity
-Types of effector mechanisms:
1-
2-
3-
Mechanisms of opsonization & phagocytosis
*phagocytosis.
*lysis by MAC.
*ADCC.
*Eosinophil-mediated cytotoxicity against parasites.
*Examples:
Complement & FC Receptor-mediated inflammation
Mechanism.
-Examples.
Ab-mediated cellular dysfunction
-Examples.
-Mechanisms.


Questions:-


Q1)Describe the mechanism of erythroblastosis fetalis.
Q2) Explain the mechanism of Mysthenia gravis.
Q3) Discuss the mechanism of Graves diseas.

Q4)Explain the mechansim of autoimmune hemolytic anemia

Q5)Write short notes on mechanism on blood trasfusion reactions

References:
___________
1-MacSween R.N.;and Whaly K.(Murs Textbook of pathology); 13th edition,Arlond.1997.
2-Kumar V.;Abbas A.; and Fausto N.(Robbin and Cortan, Pathologic basis of disease).7th edition. Elsevier Sounder. 2004.
3-Rosal J. (Ackerman s surgical pathology); 9th edition.Mosby.2003.

4-Walts J.B.,Talbot L.c.(general pathology ); 7th edition ,Churchill Livingstone; 1996 .

5-Krishna V.(Text book of pathology );Orient Longman Private limited. 2004 .