Brucellosis-CDCreport

Brucellosis

ICD-10 A23
3.2.1 Identification

A systemic zoonotic bacterial disease caused by Brucella species.

Clinical features
An illness characterized by acute or insidious onset, with continued, intermitted or irregular fever of variable duration, profuse sweating particularly at night, fatigue, anorexia, weight loss, headache, arthralgia and generalized aching. Local infection of various organs may occur.
Fever is the most common symptom and may be associated with a variety of other complaints.
Osteo-articular complications are common (20 – 60% of cases).

Case classification
Suspected: A case that is compatible with the clinical description and is epidemiologically linked to suspected or contaminated animal products.
Probable: A suspected case that has a positive Rose Bengal test.
Confirmed: A suspected or probable case that at is laboratory-confirmed through isolation of Brucella spp. From clinical specimen or Brucella agglutination titer (e.g., standard tube agglutination tests: SAT>160 IU) in one or more serum specimens obtained after onset of symptoms or ELISA (IgA, IgG, IgM) 2 -mercaptoethanol test, complement fixation test, (FAT), and radio immunoassay for counter-immunoelectrophoresis (CIEP).