Definition and Requirements for Scaffolds Used in Tissue Engineering:
A scaffold is an artificial three-dimensional frame structure that serves as a mimic of extracellular matrix for cellular adhesion, migration, proliferation, and tissue regeneration in three dimensions.
An ideal scaffold for tissue engineering should possess the following char-acteristics:
1. It is highly biocompatible and does not elicit an immunological or clinically detectable foreign body reaction.
2. It is three-dimensional and capable of regenerating tissue and organs in their normal physiological shape.
3. It is highly porous with an interconnected pore network available for cell growth and nutrient and metabolic waste transport.
4. It has a suitable surface chemistry allowing for cell attachment, migra¬tion, proliferation, and differentiation.
5. It has controllable degradation and resorption rates that match the rate of tissue growth in vitro, ex vivo, and in vivo for biodegradable or resorbable materials.
6. It possesses the appropriate mechanical properties which match those of the normal tissue and organs.
7. It has a bioactive surface to encourage faster regeneration of the tissue.
3. 2 Principles of Scaffold Design:
All tissue and organs in the body are three-dimensional structures. In order to repair and regenerate lost or damaged tissue and organs, three-dimensional scaffolds must be designed, fabricated, and utilized to regenerate the tissue similar in both anatomical structure and function to the original tissue or organ to be replaced or repaired. Therefore, certain principles of scaffold design must be established to ensure proper tissue regeneration.
المادة المعروضة اعلاه هي مدخل الى المحاضرة المرفوعة بواسطة استاذ(ة) المادة . وقد تبدو لك غير متكاملة . حيث يضع استاذ المادة في بعض الاحيان فقط الجزء الاول من المحاضرة من اجل الاطلاع على ما ستقوم بتحميله لاحقا . في نظام التعليم الالكتروني نوفر هذه الخدمة لكي نبقيك على اطلاع حول محتوى الملف الذي ستقوم بتحميله .
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