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lipid metabolism

الكلية كلية طب حمورابي     القسم الكلية ذات القسم الواحد     المرحلة 1
أستاذ المادة شهلاء خزعل عبد محمد جابك       06/06/2018 09:30:51
explain how, when and why ketone bodies are formed.
describe how lipids are transported in the blood.
explain how tissues obtain the lipids they require from lipoproteins.
explain how disturbances to the transport of lipids can lead to clinical problems.
analyse simple problems that involve disturbances to lipid transport.
explain how hyperlipoproteinaemias may be treated.
describe how amino acids are catabolised in the body.
explain the clinical consequences of a defect in phenylalanine metabolism.
explain the clinical relevance of measuring creatinine in blood and urine.
describe how ammonia is metabolised in the body.The aim of this session is that you should understand how lipids are transported
around the body in the blood stream, the clinical problems associated with lipid
transport and have an overview of nitrogen metabolism in the body.COOAcetoacetate
and -hydroxybutyrate are synthesized in the liver from acetyl~CoA.
Acetone arises from the spontaneous (non-enzymatic) decarboxylation of
acetoacetate. Normally the concentration of ketone bodies in the circulation is low (<1
mM) but this can increase in starvation (2-10mM = physiological ketosis) and in
untreated type 1 diabetes (>10mM = pathological ketosis).
The ketone bodies are water-soluble molecules, a property that allows high plasma
concentrations and their excretion in the urine (ketonuria). Acetoacetate and -
hydroxybutyrate are relatively strong organic acids and when present in high
concentrations in the plasma they may cause acidosis (ketoacidosis). Acetone is
volatile and may be excreted via the lungs. The characteristic smell of acetone (nail
varnish remover) can often be smelt on the breath of untreated type 1 diabetics.
Ketone bodies are synthesized in liver mitochondria by the following pathway

المادة المعروضة اعلاه هي مدخل الى المحاضرة المرفوعة بواسطة استاذ(ة) المادة . وقد تبدو لك غير متكاملة . حيث يضع استاذ المادة في بعض الاحيان فقط الجزء الاول من المحاضرة من اجل الاطلاع على ما ستقوم بتحميله لاحقا . في نظام التعليم الالكتروني نوفر هذه الخدمة لكي نبقيك على اطلاع حول محتوى الملف الذي ستقوم بتحميله .