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(Principles of Receptors (Session 6, Lecture 2

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الكلية كلية طب حمورابي     القسم الكلية ذات القسم الواحد     المرحلة 2
أستاذ المادة نيران كاظم فرهود الربيعي       01/04/2019 21:10:31
Principles of Receptors (Session 6, Lecture 2)
Endocytosis: Is a process by which cells internalize substances (molecules, bacteria or viruses ) by forming new vesicles from the plasma membrane. Vesicles movement brings substances in bulk into
the cell.
Endocytosis and Exocytosis continually replace and withdraw patches of the plasma membrane.
Viral Entry:
Is the earliest stage of infection in the viral life cycle, as the virus comes into contact with the host cell and introduces viral material into the cell.
* Entry via Membrane Fusion
Steps of viral-cell membrane fusion:
1- Receptor Binding : specific association with the virion and cell surface receptors
2- Virus with host membrane fusion:
3- unfolding of the viral envelope: The virus s envelope blends with
the cell membrane.
4- Release of virion contents into host cytoplasm.
This can only be done with viruses that an envelope viruses, Examples virus (Herpes simplex and HIV)
* Entry via Endocytosis
Membrane-enveloped viruses and some toxins exploit endocytic pathways to enter cells after binding to receptors in the plasma membrane.
- In the endosome, where the acid pH is favourable, the viral membrane is able to fuse with the endosomal membrane.
-the virus must now break out of the vacuole to gain access to the cytoplasm, thereby, releasing the viral RNA into the cell where it can be translated and replicated to form new viral particles,examples include the ( Poliovirus, Hepatitis C virus,Foot and Mouthe Disease Virus )

المادة المعروضة اعلاه هي مدخل الى المحاضرة المرفوعة بواسطة استاذ(ة) المادة . وقد تبدو لك غير متكاملة . حيث يضع استاذ المادة في بعض الاحيان فقط الجزء الاول من المحاضرة من اجل الاطلاع على ما ستقوم بتحميله لاحقا . في نظام التعليم الالكتروني نوفر هذه الخدمة لكي نبقيك على اطلاع حول محتوى الملف الذي ستقوم بتحميله .
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