ࡱ > c e b q` 0 Bb bjbjqPqP 3h : : " * * * 8 b | " #$ : ~ ~ ~ ~ ~ } } } ~# # # # # # # $ ]% h ' P # 9 } } # ~ ~ # ! ! ! ~ ~ ~# ! ~# ! ! ! ~ r `e * ! " l # 0 #$ ! ( ( ! ( ! L } q ! 5 } } } # # t! R } } } #$ " " " d " " " " " " Dermatoglyphic Studies In Breast Cancer Saa'd Merza Al-Araji University of Babylon College of Medicine Abstract The finger & palmer dermatoglyphics of 21 women with breast cancer and 21 normal healthy women at different ages showed that there is a decrease in whorls pattern, an increase in loops & arch patterns and a decrease in a - b ridge count in women with breast cancer compared with the healthy women. Percentage of ridge patterns of all finger tips of patients with breast cancer and normal's revealed mo s t l y l o o p s , f o l l o w e d b y w h o r l s a n d t h e n a r c h e s . T h e p r e s e n t s t u d y h a s s h o w e d d i f f e r e n c e s b e t w e e n b r e a s t c a n c e r a n d n o r m a l . 'D.D'5) *E /1'3) (5E'* 'D'5'(9 H'D.7H7 'D,D/J) D1'-) 'DJ/ AJ 2 1 'E1#) E5'() (317'F 'D+/J H 2 1 'E1#) 7(J9J) EF 'DDH'*J J*E*9F (5-) ,J/) AJ #9E'1 E.*DA). H B/ #8G1* 'D/1'3) #F GF'C 'F.A'6' AJ FE7 'D/H'E'* H2J'/) AJ 'FE'7 'D91H'* H#FE'7 'D'BH'3 H'F.A'6' AJ ( a - b r i d g e ) AJ 'DF3'! 'DE5'('* (317'F 'D+/J ('DEB'1F) E9 'DF3'! :J1 'DE5'('* ( E,EH9) 'D3J71)) . HC'F* 'DF3() 'DE&HJ) D#FE'7 'D.7H7 'D,D/J) D,EJ9 #71'A 'D#5'(9 DDE5'('* (317'F 'D+/J 7(J9J) -J+ 'F :'D(J*G' C'F JE+DG' FE7 'D91H'* *DJG' 'D/H'E'* +E 'D#BH'3. H #8G1* G0G 'D/1'3) H,H/ 'D'.*D'A'* AJ 'D.7H7 'D,D/J) (JF 'DE5'('* (317'F 'D+/J H:J1 'DE5'('*. I n t r o d u c t i o n P a l m e r a n d f i n g e r d e r m atoglyphics are formed early during intrauterine life, and their morphology can be influenced by factors interfering with normal intrauterine development (Bracha, et al, 1991, 1992). Dermatoglyphics is defined as the surface marking (sharply sculptured ridges) of the skin, especially of the palmer and plantar regions. The ridge patterns which constitute dermatoglyphics develop in the third & fourth month of fetal life. These patterns completed by the 18th week, remain unchanged apart from an increase in size and possible distortion by injury. From 1936 (Cummins , 1936, Cummins & Midlo, 1943) to the present, numerous dermatoglyphic studies have been dedicated to a wide range of pathologic disorders (Floris, 1992; Gupta, et al, 1981; Alaraji, 2003) . In fact, while a fairly clear, typical dermatoglyphic pattern emerges in aberrations involving chromosomes & growth, in genie , or in any case, probable hereditary pathologies, only few and non-utilizable differences have been noted with respect to the control group. It is therefore evident that the identification of significant differences in dermatoglyphics in frequent, serious pathological forms of high social relevance as is the case with tumours (Alaraji, 2003), may be of great importance. The diseases which have a genetic base are the most ideal to study from the dermatoglyphic point of view. Materials and Methods The present work comprises a study of palmer dermatoglyphic patterns in 21 normal women of different age group and in 21 case of patients with breast cancer. The prints were obtained and examined as cited by Alaraji (2003). The parameters considered for study included pattern in the digits , a-b ridge count, ridge count from the triradial point to the point of core and total finger ridge count. Results When the percentage of ridge patterns of all finger tips were taken into consideration loops had the highest incidence (60.2% in normals, 64.2% in breast cancer) followed by whorls (38.1% in normals; 32.6% in breast cancer) and arches (1.7% in normals ; 3.2% in breast cancer) (Table 1). Table 1: Mean values of fingertip patterns Finger patterns Normal Breast cancer Loops 60.2% 64.2% Whorls 38.1% *32.6% Arches 1.7% 3.2% Total 100% 100% *p<0.05 On examining table 2, where we find average values and standard errors for the a-b ridge count, it can be seen that breast cancer is accompanied by low values of the a-b ridge count. Table 2: Mean of interdigital ridge count, a-b ridge count in healthy women & women with breast cancer Breast cancer Normal Interdigital ridge count 76.6+1.5 77.3 1.1 a-b ridge count On examining table 3, where we find average values and standard errors of total finger ridge count in healthy women and in woman with breast cancer, it can be seen that breast cancer is accompanied by high (TFRC) values. Table 3 : Total finger ridge count (TFRC) in healthy woman & women with breast cancer Total Finger Ridge Count (TFRC) Normal Breast cancer 139.1 5.0 148.1 4.9 Discussion In comparison with other studies (Floris , 1992; Singh ,et al., 1979) which showing an increase in whorls and decrease in loops patterns, but our study showing that there were a decrease in whorls with increasing of loops and arches patterns associated with low values of a-b ridge count and high total finger ridge count in patients with breast cancer. The result obtained indicate that the disease (breast cancer) have a genetic base in women , so we can use dermatoglyphic analysis for the women in families with positive history of breast cancer. References Alaraji, S. (2003). Genetic Studies on the uterine cervix carcinoma. Ph. D. Thesis. University of Babylon. Bracha, H.; Torrey, E.; Bigelow, L.; Lohr, J. & Linington, B. (1991). Subtle Signs Of Prenatal Maldevelopment Of Hand Ectoderm. Biol. Psych., 30:319-725. 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